Areas of Research

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There will not be a single answer to epidermolysis bullosa. Each type of EB presents different challenges and presents a challenge to the technologies employed. The complexity of body systems affected will necessitate combination therapy, as in cancer treatment.

Our primary goal is to cure EB, that is to find a genetic fix, by correcting or replacing the genetic faults that underpin each type of EB.

However, we want to improve the lives of EB sufferers now, through the development of effective treatments that provide symptom relief and quality of life improvements. We also fund projects targeting the treatment of specific EB related health issues and developing new technologies towards treating all types of EB.

The research we fund falls into the following categories:

graphic of white dna strands one overlaid with scissors, one overlaid with a syringe against a blue background

Gene Therapy and Gene Editing

Gene therapy replaces or adds a new gene to correct a genetic fault; Gene editing involves the insertion, deletion or replacement of DNA.
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Cell Therapy

Cell therapy is the transplantation of human cells to replace or repair damaged tissue or cells.
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Drug Therapy

Drug therapy involves the administration of drugs to treat or slow progression of a disease.
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Protein Therapy

Protein therapy involves giving enough of the functional protein which is missing or faulty in people with EB.

EB Cancer Therapy

Patients with DDEB, RDEB, generalized JEB and Kindler Syndrome are at an increased risk of squamous cell carcinoma (SCC).

There are also several clinical trial registers worldwide where you can search for EB clinical trials:

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