Big Give Christmas Challenge 2018

November 28, 2018sharmilaUncategorized

From midday on Tuesday 27th November to midday on Tuesday 4th December, have your Christmas donation doubled through the Big Give’s Christmas Challenge.

Click here to donate!

Cure EB joins consortium to fund anti-fibrotic treatment

We’re pleased to announce that Cure EB is joining three other EB charities to fund the clinical development of a new anti-fibrotic drug called TXA127.

Click to read press release from Constant Pharmaceuticals.


Researchers discover cause of aggressive skin cancer in RDEB

Scientists at the Sidney Kimmel Cancer Center at Jefferson University have discovered the cause of aggressive skin cancers in Recessive Dystrophic Epidermolysis Bullosa (RDEB)
Click to see report from Jefferson University

First Patient Dosed with Dystrophic Epidermolysis Bullosa Treatment, KB103

Krystal Biotech announced that the first patient has been dosed in the Phase 1/2 clinical trial of its drug, KB103, for the treatment of dystrophic epidermolysis bullosa (DEB).


(source:, May 10th 2018)

CU Anschutz scientists awarded $3.8 million Department of Defense grant

String of major recent grants underlines promise of new potential treatments for Epidermolysis Bullosa and other chronic skin wounds


(source:, April 12th 2018)

‘Butterfly child’ given life-saving skin

A child has been given a new genetically modified skin that covers 80% of his body, in a series of lifesaving operations.


(source: BBC News, 8th November 2017)

Sohana speaking at #WEDay UK on 9 March 2016

June 16, 2016richardLatest News

Sohana speaking at #WEDay UK on 9 March 2016

BBC News – The promise of gene editing

December 18, 2015richardLatest News

Sharmila Nikapota, the mother of a child with a rare genetic disorder, has high hopes for gene editing…read more

Two NEW projects funded!

November 18, 2015richardUncategorized

Lenticol -M Mesenchymal Stromal Cells engineered to express Collagen VII for the treatment of RDEB

Dr Waseem Qasim, Professor J McGrath, Francesco Dazzi

Further info A trial is currently underway to test the ability of fibroblasts to provide collagen VII in the skin of patients with RDEB. The trial will provide important information on the safety and feasibility of localised injections of engineered cells into the skin. We now want to prepare for a more generalised approach using bone marrow derived cells called MSCs. This project aims to develop reagents and to test gene engineering of MSCs. It will include production of lentiviral vector and testing in an animal model, using human skin grafts from EB patients.

Deep Sequencing Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma

Dr Andrew South (Thomas Jefferson University) and Dr Raymond Cho (Department of Dermatology, University of California)

Patients with recessive dystrophic epidermolysis bullosa (RDEB) frequently develop aggressive, life-threatening cutaneous squamous cell carcinoma (cSCC). Although mechanisms have been proposed to explain why patients suffer this fatal complication, testing such hypotheses requires knowledge of which mutations contribute to the development of RDEB cSCCs. Identifying the mutational landscape of RDEB cSCCs should provide critical insight on how a cancer can develop so quickly in the absence of lifelong sun exposure and DNA damage. Understanding such mechanisms should elucidate modes of prevention and early detection unique to these patients. An increasing number of chemotherapies targeting specific gene mutations are currently in clinical use or development, thus sequencing these cancers may match a known treatment to RDEB patients. This project proposes to sequence 30 RDEB cSCC tumors and matched germ line DNA. This project aims to find tractable therapy options or targets for future development, both clinically and experimentally.

Mirror Newspaper – Schoolgirl’s skin blisters and burns if mum hugs her

September 29, 2015richardLatest News